Research Journal of Topical and Cosmetic Sciences
Year : 2015, Volume : 6, Issue : 1
First page : ( 32) Last page : ( 37)
Print ISSN : 0976-2981. Online ISSN : 2321-5844.
Article DOI : 10.5958/2321-5844.2015.00005.9

Ethosome: A Promising Approach for Antifungal Drug Delivery

Ghadge Tejashree A.*, Kulkarni A.S., Majumdar S.H., Chavare S.D.

Satara College of Pharmacy, Satara

*Corresponding Author E-mail: tejashree.ghadge77@gmail.com

Online published on 30 July, 2015.

Abstract

Topical drug delivery system is most preferred drug delivery system. Various skin infections are treated by transdermal drug delivery system. Fungal infection on skin is most commonly found disease. To treat topical fungal infection many semisolid dosage forms like ointment, cream and gels are used. These formulations have limited therapeutic efficacy stability and safety profiles. Stratum corneum layer of skin acts as major barrier for topical formulation. Ethosomes are modified lipid carrier that helps drug to reach deep into skin. Ethosomes can be considered as one of the best replacement for carrying antifungal agent. Ethosomes contain phospholipids and high concentration of alcohol in vesicular formulation. An alcohol acts as permeation enhancer and increase permeability of skin.

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Keywords

Antifungal, Ethosome, Phospholipids, Lipid carrier, Vesicular system.

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