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Year : 2020, Volume : 11, Issue : 2
First page : ( 77) Last page : ( 82)
Print ISSN : 0976-2981. Online ISSN : 2321-5844.
Article DOI : 10.5958/2321-5844.2020.00014.X

Potential role of peptides for development of cosmeceutical skin products

Yadav Akshay R.1*, Mohite Shrinivas K.1

1Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Dist-Sangli, Maharashtra, India-415404.

*Corresponding Author E-mail: akshayyadav24197@gmail.com

Online published on 10 February, 2021.


Peptides are considered to be useful in cosmetics because they are light and air stable, less harmful, have a good water affinity and have a moisturizing capacity. They are widely utilized to improve skin conditions in functional cosmetic products which contain antioxidants, anti-inflammatory, synthesis of collagen, antiwrinkle and wound healing effects. Dermal-epidermal junction (DEJ) is an interface between the epidermis and the dermis, physically and biologically. The DEJ also acts as a passageway for molecular transport, in addition to providing structural integrity. DEJ's recent importance in skin aging has tested new peptide derivatives for their effect in cultured human epidermal keratinocytes on the signals of the basement membrane (BM). The study peptides and peptides complex induced protein expressions of collagen XVII, laminin and nidogen. Further examination of the excised human skin indicates a substantial increase in the expressions of dermal collagen and of collagens XVII and laminine in topical application of the peptides complex. This article summarizes biological activities of peptides related to their potential cosmeceutical application in-silico, in vitro and in vivo evidence.



Peptides, Antiwrinkle, Skin aging, Protein expressions, Cosmeceutical applications.


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