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Research Journal of Science and Technology
Year : 2020, Volume : 12, Issue : 4
First page : ( 317) Last page : ( 322)
Print ISSN : 0975-4393. Online ISSN : 2349-2988.
Article DOI : 10.5958/2349-2988.2020.00047.9

Terahertz pulse imaging spectroscopy and pharmaceutical applications - a review

Tambe Varsha N.1*, Jadhav Priyanka S.1, Tambe Avinash N.2

1Department of Quality Assurance Technique, MGV’s Pharmacy College, Panchavati, Nashik, Maharashtra

2Department of Chemistry, Padmashri Dr. Vitthalrao Vikhe Patil College of Art, Science and Commerce, Pravaranagar

*Corresponding Author E-mail: varshatambe2015@gmail.com

Online published on 29 January, 2021.

Abstract

The terahertz region of the electromagnetic spectrum spans the frequency range between the mid-infrared (IR) and the millimeter/microwave. THz spectroscopy or imaging can be utilized for improving quality and uniformity of pharmaceutical products, such as identifying polymorphic forms, measuring tablet coating thickness, and 3D chemical mapping. These properties contribute greatly to drug dissolution and bioavailability. This review outlines some of the recent pharmaceutical applications of terahertz spectroscopy and imaging.

The following application areas are highlighted:

1. Discrimination and quantification of polymorphs/hydrates.

2. Analysis of solid form transformation dynamics.

3. Quantitative characterization of tablet coatings: off-line and on-line.

4. Tablet coating and dissolution.

5. Spectroscopic imaging and chemical mapping.

This review does not attempt to offer an exhaustive assessment of all anticipated pharmaceutical applications; rather it is an attempt to raise the awareness of the emerging opportunities and usefulness offered by this exciting technology.

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Keywords

Introduction, Principle, Instrumentations and Pharmaceutical Applications.

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