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Research Journal of Science and Technology
Year : 2020, Volume : 12, Issue : 3
First page : ( 211) Last page : ( 221)
Print ISSN : 0975-4393. Online ISSN : 2349-2988.
Article DOI : 10.5958/2349-2988.2020.00029.7

Analytical method development and validation of ramipril and hydrochlorothiazide- a review

Landge Kushal Ramdas1,*, Siddheshwar Suhas2, Ghogare Rajashree2

1Research Scholar, M Pharmacy, Pravara Rural College of Pharmacy, Pravaranagar

2Assistant Professor, Pravara Rural College of Pharmacy, Pravaranagar

*Corresponding Author E-mail: kushal.landge555@gmail.com

Online published on 16 September, 2020.


Ramipril is a potent long acting ACE inhibitor and Hydrochlorothiazide is a thiazide diuretic and an antihypertensive. In literature few analytical methods are discussed for the estimation of Ramipril and Hydrochlorothiazide. The objective of this study is to develop and validate RP-HPLC method for the qualitative estimation of the drug. In most of the methods, the isocratic elution was carried out by using Acetonitrile, water and buffer as a mobile phase. The wavelength was in between 210 to 215nm for Ramipril and 316nm for Hydrochlorothiazide. The flow rate was approximately 0.8ml/min to 1.0ml/min. The temperature set was ambient temperature. The developed methods were validated as per ICH guidelines and this method were found to be specific, precise, sensitive and robustness.



Ramipril, Hydrochlorothiazide, RP-HPLC method, Antihypertensive, ACE inhibitor, Validation. System suitability, Stability-indicating, Pharmaceutical dosage form, ICH.


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