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Research Journal of Science and Technology
Year : 2020, Volume : 12, Issue : 1
First page : ( 74) Last page : ( 78)
Print ISSN : 0975-4393. Online ISSN : 2349-2988.
Article DOI : 10.5958/2349-2988.2020.00010.8

Development and Validation for Simultaneous Estimation of Gabapentin, Mecobalamin and Alpha Lipoic Acid in Tablet Formulation

Chandak Dilip*, Sharma Pushpendra

Department of Chemistry, Sri Satya Sai University of Technology & Medical Sciences, Sehore-466001, Madhya Pradesh, India

*Corresponding Author E-mail: dilip_chandakmam@rediffmail.com



The purpose of this study is to develop simple, economic, specific, rapid, reliable, and reproducible method for simultaneous estimation of the Gabapentin, Mecobalamin and Alpha lipoic acid


In this method the overlapping spectra of Gabapentin, Mecobalamin and Alpha lipoic acid were well resolved by making use of the first-derivative of the ratios of their direct absorption spectra. The derivative ratio absorbance of Gabapentin, Mecobalamin and Alpha lipoic acid were measured at 731.10nm, 768.53 nm and 242.21nm for their quantification. The method was validated for accuracy, precision, linearity, robustness and sensitivity

Result and Discussion

Gabapentin, Mecobalamin and Alpha lipoic acid were shown linearity in the concentration range of 100e500 mg/ml, 0.5e2.5mg/ml and 100e500mg/ml respectively. The LOD and LOQ were found to be 3.09mg/ml and 9.37mg/ml; 0.03 mg/ml and 0.10mg/ml; and 4.79mg/ml and 14.52mg/ml respectively. The % labelled claim for Gabapentin, Mecobalamin and Alpha lipoic acid were found to be 98.71, 98.94 and 98.44 respectively


Thus, the described method is suitable for routine analysis and quality control of pharmaceutical preparations containing these drugs in combination.



Gabapentin, Mecobalamin, Reproducible method.


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