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Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 9
First page : ( 1433) Last page : ( 1440)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00277.8

Greener Synthesis of some Bioactive 2, 5-Disubstituted-1, 3, 4-Oxadiazoles

Vora Parin K., Dr. Somani Rakesh R.*, M Jain adhuri H., Parab Sonali S., Patil Pallavi M.

Department of Pharmaceutical Chemistry, Vivekanand Education Society's College of Pharmacy, Hashu Advani Memorial Complex, Behind Collectors Colony, Chembur, Mumbai-74, India

*Corresponding Author E-mail: rakeshrsomani@gmail.com/voraparin476@gmail.com

Online published on 12 January, 2017.


In the present paper, a series of substituted 1, 3, 4-oxadiazoles have been synthesized by three different methods i.e. conventional heating, microwave irradiation method 1 and microwave irradiation method 2. Conventional heating, microwave irradiation method 1 and microwave irradiation method 2 were compared in terms percent yield, reaction time, percent atom economy and environment quotient (eco-friendly). The results showed that microwave irradiation method 2 was remarkably greener and ecofriendly than microwave irradiation method 1 and conventional heating. Derivatives of 1, 3, 4-oxadiazoles were characterized on the basis of IR, 1H NMR and Mass spectral data and the structures of the synthesized compounds were confirmed. All compounds were screened for their in vitro antibacterial, antitubercular and antifungal activity. However the results indicated that the synthesized compounds have less activity with reference to their respective standards.



1, 3, 4-oxadiazoles, Microwave heating, conventional heating, solventless synthesis, Montmorillonite K-10.


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