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Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 8
First page : ( 1268) Last page : ( 1276)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00241.9

Mosquito, Malaria and Medicines-A Review

Thillainayagam Mahalakshmi, Ramaiah Sudha*

Medical and Biological Computing Laboratory, School of Biosciences and Technology. VIT University, Vellore-632 014, Tamil Nadu, India

*Corresponding Author E-mail: sudhaanand@vit.ac.in

Online published on 12 January, 2017.

Abstract

Malaria is one of the important mosquito-borne parasitic infectious diseases in the world. It is caused by protozoa of the genus Plasmodium. It is an emerging communicable disease in both tropical and non tropical countries. More than million malarial deaths are reported every year especially among children. The emerging resistance to current therapy by P. falciparum has created an alarming need for the design and development of safe and effective drugs with good pharmacokinetic parameters. This can be achieved by having the knowledge about the disease causing organism, its growth pattern, clinical symptoms of disease and current dosage regimen. Considering these requirements, the current review work is carried out which briefs about the history and emergence of malarial fever, the discovery of its cause, the life cycle of parasite in mosquitoes and human being, the outlook on classification of malaria and the pharmacological classification of malarial drugs with their pharmacokinetic and pharmacodynamic parameters.

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Keywords

History of malaria, life cycle of Plasmodium, Anti-malarial drugs, Pharamacokinetics of antimalarial drugs, Pharmacodynamics of antimalarial compounds.

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