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Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 8
First page : ( 1161) Last page : ( 1165)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00221.3

Microwave Synthesis of Some Novel 2-Substituted and N-Substituted Benzimidazole Derivatives and its Antimicrobial Activity

Kore Pankaj S*, Honmane P.P., Barkade R.P., Mohite S.K., Magdum C.S.

Department of Pharmaceutical chemistry, KES's Rajaram Bapu College of Pharmacy, Kasegaon, Maharashtra, (India)

*Corresponding Author E-mail: pkpankajpk3@gmail.com

Online published on 12 January, 2017.

Abstract

Benzimidazole and its derivatives represent one of the most biological active classes of literature. Two series of Benzimidazole derivatives were synthesized by the condensation reaction between o-phenylenediamine and carboxylic acids in presence of ring closing agents like HCl. The chemical structures of synthesized compounds were identified by the spectral analysis. The purity of compounds was determined by thin layer chromatography (TLC). The synthesized compounds have been screened for their antimicrobial activity by paper disc method.

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Keywords

Benzimidazole derivatives, characterization, microwave, antimicrobial activity.

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