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Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 8
First page : ( 1115) Last page : ( 1118)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00211.0

Anticancer Activity of Ethyl Acetate Root Extract of Xanthium strumarium Linn. in N-Nitroso N-Methyl Urea Induced Mammary Carcinoma in Female Sprague-Dawley Rats

Milton John. D.1,*, Jose M. Alvin2

1PRIST University, Vallam, Thanjavur-613403, Tamil Nadu, India

2Swamy Vivekananda College of Pharmacy, Elayampalayam, Tiruchengode-637205, Namakkal District, Tamil Nadu, India

*Corresponding Author E-mail: jdmilton_1976@yahoo.co.in

Online published on 12 January, 2017.

Abstract

The objective of the study was to evaluate the anticancer activity of ethyl acetate root extract of Xanthium strumarium Linn. (EAREXS) in N-Nitroso N-methyl urea (NMU) induced mammary carcinoma in female Sprague-Dawley rats. Thirty virgin female Sprague-Dawley rats of 55 day old were divided into five groups (normal control, disease control, EAREXS 200 mg/kg, EAREXS 400 mg/kg, tamoxifen10 mg/kg) of six animals each. The mammary carcinoma was induced by two intraperitoneal doses of N-Nitroso N-methyl urea (NMU) (50mg/kg/body weight each) in 0.9% NaCl (maintained at 4°C) at 55 day of age and 4 week after the prior administration. The drug EAREXS was administered in two doses, 200 mg/kg, and 400 mg/kg orally and compared with the oral dose of tamoxifen (10 mg/kg). EAREXS 200 mg/kg, 400 mg/kg, and tamoxifen10 mg/kg decreased the tumor incidences by 50%, 66.67%, and 83.33% and the total number of tumors in group by 46.15%, 69.23% and 92.30% respectively, when compared to the disease control. EAREXS 200 mg/kg, 400 mg/kg, and tamoxifen10 mg/kg decreased the average tumor burden by 68.61%, 86.65% and 94.91% and average tumor volume by 66.45%, 82.01%, and 92.98% respectively, when compared to disease control group. The results concluded that EAREXS prevent the mammary carcinogenesis induced by N-Nitroso N-methyl urea in female Sprague-Dawley rats.

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Keywords

Mammary Carcinoma, tamoxifen, N-Nitroso N-methyl urea.

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