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Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 8
First page : ( 1086) Last page : ( 1090)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00207.9

Preparation and Characterization Vagino-adhesive Fluconazole Gel

Choudhury Ananta*, Roy Amit

Department of Pharmaceutics, Columbia Institute of Pharmacy, Tekari, Raipur, C.G.

*Corresponding Author E-mail: anantachoudhury@gmail.com

Online published on 12 January, 2017.


The objective of the present investigation was to prepare and characterize a vagino-adhesive fluconazole gel and to find out suitable polymer systems that may efficiently fulfill the need. Different mucoadhesive polymers including HPMC E 4000 (4–6% w/w), Carbopol 934(0.5–1.5% w/w), Carbopol 940 (0.5–1.5% w/w), Guar gum (3–5% w/w) and Na CMC (3–5% w/w), were used to develop gel along with fluconazole (1% w/w). The Vaginoadhesive properties of the gels were assessed using sheep vaginal mucosa under pH 4.5 citrate-phosphate buffer at 37°C. In-vitro drug release profiles of the gels were determined in pH 4.5 citrate-phosphate buffer. Other important evaluation parameters like viscosity, pH, bioadhesion time, Spreadibility, Drug content, in-vitro drug release study were also performed to assess the prepared formulations. Results indicated that, formulation fabricated with carbopol 934, carbopol 940 and HPMC E 4000 are the polymers shown better performance as compare to others. Among the several formulations, F3, F6andF7 found more efficient.



Fluconazole, vaginal gel, Mucoadhesive, Vagino-adhesive.


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