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Statins: Pleiotropic Effect Ashna A, Jeena S, Vidhya PV, Venkateswaramurthy N.*, Sambathkumar R. J.K.K. Nattraja College of Pharmacy, Kumarapalyam, Tamil Nadu, India *Corresponding Author E-mail: venkateswaramurthy.n@jkkn.org
Online published on 15 October, 2016. Abstract Statins are most effective in reducing the plasma cholesterol level by inhibiting hydroxyl methyl glutaryl coenzyme A reductase. Emerging evidence suggest that statins exert other mechanism of action called Pleiotropic effects; which are plaque stability, endothelial function modification, thrombus formation etc. Therefore therapeutic potential of statins extends beyond lipid lowering. Correctly underlying these pleiotropic effect suggest a new method to prevent and treat wide variety of life threatening disorders. Thus statins has added a wide scope of potential targets ranging from acute coronary syndrome to other renal infections and neuroleptic disorders. Top Keywords Pleiotropy, hypolipemic agents, HMG CoA Reductase Inhibitors. Top | |
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