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Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 7
First page : ( 817) Last page : ( 830)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00156.6

Development and Optimization of Oral Gastroadhesive Matrices for Diltiazem Hydrochloride Using Some Natural Materials

Shende M.A.1,*, Marathe R.P.2

1Department of Pharmaceutics, Government College of Pharmacy, Kathora Naka, Amravati, Maharashtra-444604, India

2Government College of Pharmacy, Peer Bazar Road, Opp., Osmanpura, Aurangabad, Maharashtra-431005, India

*Corresponding Author E-mail: shende_mulchand@rediff.com

Online published on 15 October, 2016.

Abstract

The present aim of this wok was to formulate gastric retentive tablets by gastroadhesion with a view to provide better absorption employing combination of hibiscus esculentus mucilage and xanthan gum for diltiazem hydrochloride. Various formulations of diltiazem hydrochloride were prepared by wet granulation technique using Box-Behnken approach and were tested for compatibility, swelling behaviour, in-vitro drug release, mucoadhesive strength and accelerated stability. The percent cumulative drug release at 8th hr (Y1), time to release 80% of drug (Y2), mucoadhesive strength (Y3) and mucoadhesive time (Y4) were used as the formulation responses in order to optimize the formulation. The accelerated stability studies revealed that the tablets retained their characteristics even after stressed storage conditions. The DLT mucoadhesive matrices were 49.99 mg hibiscus esculentus mucilage, 44.97 mg xanthan gum and 4.48 ton compression load fulfilled the optimal criteria of best sustained release rate and bioadhesive characteristics with t80% of 7.6 h, Q8h of 89.83% and bioadhesive strength of 22.14 g. The formulated tablets ascertained first order kinetics and followed peppas mechanism.

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Keywords

Diltiazem hydrochloride, Hibiscus esculentus, Xanthan gum, Gastroadhesive, Box-Behnken.

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