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Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 7
First page : ( 805) Last page : ( 809)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00154.2

Development and Evaluation of Lozenge from Moringa oleifera leaf extract

Panya Thanakorn1, Dr. Chansri Narin2, Dr. Daodee Supawadee3,*

1Master Student, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, Thailand, 40002

2Lecturer, Division of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, Thailand, 40002

3Associate Professor, Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, Thailand, 40002

*Corresponding Author E-mail: csupawad@kku.ac.th, supawadeedaodee@gmail.com

Online published on 15 October, 2016.

Abstract

Purpose

To develop and evaluate a model lozenge from Moringa oleifera leaf extract.

Methods

Lozenge from M. oleifera leaf extract was developed and formulated using wet granulation technique. Lozenges were evaluated for physicochemical properties such as thickness, hardness, friability and weight variation. Assay of quercetin content was also determined by HPLC for the preliminary stability testing and drug released study.

Results

The appropriate lozenge formulation containing M. oleifera leaf extract powder, polyvinylpyrrolidone, magnesium stearate, menthol and vanillin showed a good physicochemical properties which all the criteria value were in the acceptable range. Moreover, the microbial testing showed no contamination of any microorganisms in proper formulations.

Conclusion

The results indicated the development of a suitable lozenge formulation from M. oleifera leave extract which should be further study and apply to the other herbal formulations in the future.

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Keywords

Moringa oleifera, lozenge, quercetin, HPLC, herbal formulation.

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