Study on the adverse reactions of antipsychotics and therapeutic drug monitoring of olanzapine in psychiatric patients
Menaka K1,*, Sarumathy S2, Sivakumar T1
1Department of Pharmacy Practice, Nandha College of Pharmacy, Koorapalayam Pirivu, Pitchandampalayam Post, Erode-638 052, Tamil Nadu, India
2Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels University (VISTAS), Pallavaram, Chennai-600117, Tamil Nadu, India
*Corresponding Author E-mail: firstname.lastname@example.org
Online published on 21 July, 2016.
Antipsychotics used in the treatment of psychotic disorders such as schizophrenia are generally associated with potential adverse effects. They mainly act by blocking dopaminergic uptake by binding to its receptors in the post synaptic nerve terminals. However their potential peripheral and extra pyramidal adverse effects have led to patient non-compliance of medications. Hence a clear understanding of the adverse effects associated with antipsychotic therapy could ultimately yield better therapeutic outcomes and increase patient adherence to medications. The study was designed to analyse the common adverse reactions caused by antipsychotic medications. Olanzapine was found to be associated with greater risk of adverse effects and hence the plasma concentration of olanzapine was monitored.
Psychotic disorders, Adverse drug reactions, Therapeutic drug monitoring, Olanzapine, Weight gain.