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Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 5
First page : ( 571) Last page : ( 580)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00108.6

Advances in Granulation Technology

Sahoo Chinmaya Keshari1,*, Rao Surepalli Ram Mohan2, Sudhakar Muvvala3, Bhaskar Jimidi4

1Ph. D Scholar, Department of pharmaceutics, Osmania University College of Technology, Osmania University, Hyderabad, Telangana-500007

2Professor, Mekelle Institute of Technology, Mekelle University, Mekelle, Ethiopia

3Professor and Principal, Department of pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Telangana-500014

4Associate Professor, Department of pharmaceutics, Princeton College of Pharmacy Korremula, Rangareddy, Telangana, 500088, India

*Corresponding Author E-mail: Sahoo.chinmaya83@gmail.com

Online published on 21 June, 2016.

Abstract

Granulation is used in the production of pharmaceutical oral dosage forms. It improves flow and compression characteristics, reduces segregation, improves content uniformity and eliminates excessive amounts of fine particles. The results can be improved yields, reduced tablet defects, increased productivity and reduced down time. Pharmaceutical products are processed all over the world using various granulation methods. The method depends on the ingredients individual characteristics and ability to properly flow, compresses, eject and disintegrate. Selection of method requires thorough investigation of each ingredient in the formula, the combination of ingredients and how they work with each other. Then the proper granulation process can be used. The present review article focuses on the novel granulation technology.

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Keywords

Granulation, Compression, Oral, Flow.

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