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Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 5
First page : ( 545) Last page : ( 548)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00103.7

Synthesis and Antimicrobial Evaluation of Some Novel Derivatives of Coumarin Moiety

Kumar Abhishek*, Shetty Prerana, Amrutha C. L., Vaz Derin Reona, Baby Ashlin

Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, NITTE University, Paneer, Deralakatte-575018, Mangalore, Karnataka

*Corresponding Author E-mail: abhi12bunty@gmail.com

Online published on 21 June, 2016.

Abstract

A series of novel substituted 3-(2-hydroxy-6-phenylpyrimidin-4-yl)-2-H-chromen-2-one and 3-(2-mercapto-6-phenylpyrimidin-4-yl)-2-H-chromen-2-one (APY1-APY8) were synthesized upon refluxing ethanolic solution of 3-(3-phenylacryloyl)-2-H-chromen-2-one with urea/thiourea in presence of 20% KOH. The structures of the final synthesized compounds were characterized by IR, mass and 1H NMR spectra. The synthesized compounds were screened for their antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa by cup plate method. Most of the compounds exhibited promising antibacterial activity.

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Keywords

Chalcones, pyrimidines, 3-acetyl coumarin, antibacterial activity.

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