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Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 3
First page : ( 313) Last page : ( 321)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00057.3

Comprehensive Review: Controlled Release Gastro-Retentive Muco-adhesive Microspheres

Bobade N.N.*, Pande S.D., Tapar K. K., Ambalkar P.V., Malviya S.P.

Vidyabharati College of Pharmacy, C. K. Naidu, Camp Road, Amravati, Dist -Amravati, State-Maharashtra, India – 444601

*Corresponding Author E-mail: nishan01_vicky@yahoo.co.in

Online published on 18 April, 2016.


The aim of this study is to review the gatro-retentive muco-adhesive microspheres, basic anatomy of stomach and its physiology, introduction of gastro-retentive drug delivery system, muco-adhesive (bio-adhesive) systems, mechanism of muco-adhesion, methods of preparation of muco-adhesive microspheres and evaluation of controlled release muco-adhesive microspheres. Gatro-retentive drug delivery system which remains in stomach for long duration of time, during which drug release in controlled manner. Muco-adhesion is one of the approaches of gastric retention by attaching to mucin in stomach to enhance residence time. For muco-adhesion different polymer (s) may used. Muco-adhestive microspheres have most of advantage for patient compliance as it is multi unit particle drug delivery system. Muco-adhesive microspheres may prepared by different method such as Complex Coacervation, Hot Melt Micro-Encapsulation, Emulsification-Internal Gelation Technique, Double Emulsion Method, Solvent Removal, Iono-Tropic Gelation, Phase Inversion Method and Spray Drying. Gastro-retentive muco-adhesive microspheres evaluated for percentage yield, particle size determination, determination of particle size distribution and zeta potential, micromeritic studies, drug entrapment efficiency, scanning electron microscopy, Muco-adhesive property of microspheres, in vitro drug release study, kinetics of drug release, and stability studies.



Gastro-Retentive, Muco-Adhesive Microspheres.


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