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Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 3
First page : ( 275) Last page : ( 280)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00051.2

Drug Interactions of H2 Receptor Antagonists-Ranitidine: A Review

Ahmad Sarfaraz1,*, Md. Ali Sajid1, Alam Nawazish1, Md. Alam Intakhab1, Md. Alam Sarfaraz1, Md. Ali Daud2

1College of Pharmacy, Jazan University, Jazan, KSA

2Department of Pharmacy, Mohammad Al-Mana College for Health Sciences, Al Khobar, KSA

*Corresponding Author E-mail: sarfaraz3030@gmail.com

Online published on 18 April, 2016.


Ranitidine has OTC drug status as well as it is an essential drug by WHO, hence it is popularly selling drug from community and hospital pharmacy. Many prescription and nonprescription drugs were found having drug interaction with ranitidine which may lead to either drug toxicity or therapy failure. This review compiles potential drug interactions of ranitidine with several categories of drugs along with effective measures. Ranitidine is in a group of drugs called histamine-2 blockers. H2 receptor antagonists continue to be prescribed usually for acid –peptic disease. Their safety record finally led to their availability as “Over the Counter” drugs. Histamine is a naturally-occurring chemical that stimulates cells in the stomach (parietal cells) to produce acid. H2-blockers inhibit the action of histamine on the cells, thus reducing the production of acid by the stomach. Ranitidine hydrochloride is prescribed for conditions such as gastroesophageal reflux disease (GERD), ulcers, Zollinger-Ellison syndrome, erosive esophagitis, upper gastrointestinal bleeding, heartburn, and other conditions where reduction of gastric secretion and acid output is desirable.



Ranitidine, Drug interaction, H2 receptor antagonists, GERD, OTC.


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