Formulation and evaluation of extended release hard capsules of Furosemide Mhanna Zain1,*, Dr. Ibrahim Wehad2, Dr. Hammad Tamim3 1Master Student, Pharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, Tishreen University, Syria. Syria-Lattakia 2Doctor in Pharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, Tishreen University, Syria. Syria-Lattakia 3Assistant Professor in Pharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, Tishreen University, Syria. Syria-Lattakia *Corresponding Author E-mail: zain.mhanna@gmail.com
Online published on 18 April, 2016. Abstract The aim of the present study is to prepare extended hard capsules of Furosemide using Eudragit RL, Eudragit RS and Ethyl cellulose individually in different ratios (6, 8, 12, and 15%) and different particle size of granules. The granules were prepared by wet granulation and then filled into capsules. The influence of different concentrations of polymer, type of polymer and granules size was studied. The prepared capsules assessed for their physicochemical properties and in-vitro drug release studies. The in vitro release data show that Ethyl cellulose has more retardation than Eudragits, and Eudragit RS retards drug release more than Eudragit RL does. In addition, higher concentration of polymer enhances the retardation better than lower concentration, and increasing the particle size of granules can alter the release of drug. Top Keywords Hard capsules, Furosemide, Wet granulation, Ethyl cellulose, Eudragit RS, Eudragit RL. Top |