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Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 12
First page : ( 2257) Last page : ( 2260)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00455.8

Synthesis and biological evaluation of some novel pyrazoline incorporated 2-quinolones

Kumar Abhishek*, Fernandes Jennifer, Kumar Pankaj

Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte-575018, Mangalore, Karnataka

*Corresponding Author E-mail: abhi12bunty@gmail.com

Online published on 2 March, 2017.

Abstract

A series of novel substituted 1-amino-3-(5-phenyl-4, 5-dihydro-1H-pyrazol-3-yl)quinolin-2(1H)-one (AJP1-AJP8) have been synthesized upon reaction with 1-amino-3-cinnamoyl-quinolin-2(1H)-one using hydrazine hydrate as cyclising agent in alcohol medium. 1-amino-3-cinnamoyl-quinolin-2(1H)-one were synthesized by condensing 3-acetyl-1-amino-quinolin-2-one with different substituted benzaldehyde in presence of ethanolic KOH. The structures of the final synthesized compounds were characterized by IR, 1H NMR and mass spectra. The final synthesized compounds were screened for their antioxidant activity by DPPH radical scavenging method and in vitro cytotoxic activity against Ehrlich Ascites Carcinoma cells (EAC) by Trypan blue exclusion method.

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Keywords

Chalcones, Pyrazoline, 2-Quinolone, Antioxidant activity, Cytotoxic activity.

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