(3.236.98.69)
Users online: 3044    [ij] [ij] [ij] 
Email id
 

Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 12
First page : ( 2169) Last page : ( 2179)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00440.6

Formulation and evaluation of floating effervescent domperidone tablets

Akelesh T*, Rajagopal Venkidesh, Chander J Sam Johnson Udaya, Manavalan R, Venkatanarayanan R

RVS College of Pharmaceutical Sciences, Coimbatore, Tamil Nadu, India

*Corresponding Author E-mail: tmakelesh@gmail.com

Online published on 2 March, 2017.

Abstract

The main objective of the study was to formulate floating tablets of Domperidone for sustained release of the drug. Floating tablets increase the gastric retention time, since domperidone is poorly absorbed in lower intestinal tract, the floating system will increase the bioavailabilty of the drug. The tablets were prepared by wet granulation method using Iso Propyl Alcohol. The tablets were prepared using polymers such as Hydroxy Propyl Methyl Cellulose, Methyl cellulose, and other excipients such as Sodium Carbonate, Lactose, Dicalcium Phosphate, Talc, Magnesium Stearate, etc. The polymers were found to be compatible with drug in FTIR study. Nine batches of tablets (DF1-DF9) were prepared using polymers at various ratios. Preformulation parameters like Bulk density, Tapped density, Carr's Compressibility index, Hausner's ratio, Angle of Repose were determined and were found to be within the limits. The tablets were evaluated for Thickness, Hardness, Friability, Weight Variation, Content uniformity. In vitro drug release study was conducted in USP Dissolution apparatus type II (Paddle type) using 0.1 N HCl as dissolution medium. It was found that the formulation DF9 released maximum drug and remained buoyant till the end of 12th hour. This formulation was subjected to stability studies for about 3 months as per ICH guidelines and was found to be stable.

Top

Keywords

Domperi done, Floating tablet, Gastroretentive drug delivery, Sustained release, Effervescent.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
498,108,637 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.