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Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 10
First page : ( 1699) Last page : ( 1703)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00342.5

Cytomorphometric and nucleomorphometeric analysis in patients with malignant lesion, patients with associated habits but with apparently normal mucosa and control group

Harsha L1,*, Dr. Gheena S.2, Shah Khushali. K.1

12nd BDS, Saveetha Dental College and Hospitals, Chennai-600 077

2Reader, Department of Oral Pathology, Saveetha Dental College and Hospitals, Chennai-600 077

*Corresponding Author E-mail: slashhania@gmail.com

Online published on 2 March, 2017.



The aim of the study is to evaluate the dysplastic changes, changes in the cell and nuclear morphology and diameter in Buccal smears of patients in study groups.


Oral exfoliative cytology is a simple and relatively pain free procedure. Oral exfoliative cytological technique has been used for the detection of oral premalignant malignant lesions. In exfoliative cytology various parameters such as nuclear size, cell and nuclear pleomorphism, nuclear membrane discontinuity, degenerative changes of nucleus and nuclear cytoplasmic ratio can be analysed.

Materials and method

Smears were taken from the buccal mucosa of 10 patients with malignant lesion, 10 patients with associated habits but apparently normal mucosa and 10 healthy individuals (control group). All the smears were stained and evaluated using research microscope and image analysis software.


To explore the potential of Exfoliative cytology as a diagnostic adjunct in patients with malignant disorders and in patients with associated habits but apparently normal mucosa.


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