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Research Journal of Pharmacy and Technology
Year : 2015, Volume : 8, Issue : 9
First page : ( 1247) Last page : ( 1249)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2015.00226.7

A novel methodology for the synthesis of teriflunomide using hydrotropes as a reaction media

Surve Yashwant S.*, Panchal Dharmesh G., Lokhande R.S

Department of Chemistry, School of Basic science, Jaipur National University, Jaipur

*Corresponding Author E-mail: yashwantsurveresearch@gmail.com

Online published on 28 October, 2015.

Abstract

This paper describes the synthesis of teriflunomide (Active pharmaceutical ingredients), used in the treatment of multiple sclerosis. The synthesis of teriflunomide was carried out using three different hydrotropes. The effect of these hydrotropes on yield, quality of product was studied at two different temperature conditions.

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Keywords

Cumene sulfonic acid (CSA), Xylene sulfonic acid (XSA), p-toluene sulfonic acid (PTSA).

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