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Research Journal of Pharmacy and Technology
Year : 2015, Volume : 8, Issue : 4
First page : ( 369) Last page : ( 375)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2015.00062.1

Studies on the anti-fertility efficacy of Abrime and Embrelin, the compounds of plant origin on mouse testis and uterus

Kavya R.1, Vivekanandan O.S.2,*, Radhai R.3

1Department of Pharmacology, Saveetha Dental College, Poonthamalle, Chennai -600077, India

2Department of Biotechnology/Bioinformatics, Vels University, Pallavaram, Chennai -600117, India

3Research Student, Department of Biotechnology, Vels University, Chennai – 600117, India

*Corresponding Author E-mail: oyessvi70@rocketmail.com, rkavyagr8@gmail.com

Abstract

The abortifacient contraceptive drugs (Allopathic) available in the market are regularly taken by women. It may result with many side effects and damage the vital organs, genetic material leading to mutational changes which in-turn prove to be carcinogenic. Abrine and Embelin, the antifertility agents of plant orgin were tested on the uterus, testis, foetuses of mice. The results were indicated that these compounds are toxic to the foetuses, uterus and testis of mice by reducing the spermatozoid production, hypertrophic and haemorrhageic uterus and also anomalies in the morphology and skeletal system of foetuses. The present study revealed that these compounds are also inducing high mutation rate. Hence, these compounds may be used as antifertility or abortifacient agents after further analysis for the safe usage by women as well as men.

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Keywords

Abortifacient, Mutation rate, Hypertrophic, Skeletal system, Antifertility agents.

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