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Research Journal of Pharmacy and Technology
Year : 2015, Volume : 8, Issue : 12
First page : ( 1733) Last page : ( 1739)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2015.00311.X

Liquisolid Technology: A Novel Approach to Enhance Solubility of Poorly Water Soluble Drugs

Patel Bhumi B.1,*, Dr. Shah Chainesh N.2, Dr. Shah Rumit M.2, Dr. Shah Dhiren P.3

1M. Pharm., Department of Pharmaceutics, Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh-394 345, Gujarat, India

2Assistant professor, Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh-394 345, Gujarat, India

3Principal, Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh-394 345, Gujarat, India

*Corresponding Author E-mail: patelbhumi198@gmail.com

Online published on 1 January, 2016.

Abstract

Solubility, Dissolution rate and Bioavailability are the main parameters on which therapeutic effectiveness of a drug depends. The limited solubility of drug is challenging point during development of the ideal solid dosage form. Liquisolid system is a novel and promising approach to enhance aqueous solubility, dissolution rate as well as bioavailability of water insoluble solid drugs or liquid lipophilic drugs by conversion of liquid drugs, drug suspensions or drug solution in non-volatile solvents, into dry, non-adherent, free flowing and compressible powder mixtures by simple blending with selected carriers and coating materials. This technology is based on a new mathematical model proposed by Spireas et al. The three main proposed mechanisms by which bioavailability of drug is increased that are increased surface area of drug, increase aqueous solubility of drug and improved wettability of the drug.

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Keywords

Poorly Soluble Drugs, Liquisolid System, Carrier and Coating Material, Wettability, Solubility.

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