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Research Journal of Pharmacy and Technology
Year : 2015, Volume : 8, Issue : 12
First page : ( 1609) Last page : ( 1614)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2015.00288.7

Dyslipidemic and Antioxidant activity of Piper longum extract in hyperlipemic rats

Dr. Verma Prabha1, Dr. Sutrakar Suresh Kumar2,*

1Lecturer & Head, Department of Biochemistry, M.L.B. Medical College, Jhansi, (U.P.), India-284001

2Associate Professor, Department of Pathology, S.S. Medical College and Asso. S.G.M. Hospital, Rewa, (M.P.), India-486001

*Corresponding Author E-mail: sutrakar.skumar35@gmail.com

Online published on 1 January, 2016.


The dyslipidemic and antioxidant activity of Piper longum extract has been studied in triton and high fat diet fed hyperlipemic rats. The extract lowered the serum lipids at (200 mg/kg, b.w., p.o.) in triton WR-1339 induced hyperlipidemia. Chronic feeding of this extract (100 mg/kg, b.w.) in animals simultaneously fed with high fat diet (HFD) for 30 days caused lowering of lipid and apoproteins level of lipoproteins in experimental animals. P. langum activates lipolytic enzymes in plasma and liver lipids. These extract increased faecal bile acid extraction and enhanced plasma lecithin: cholesterol acyltransferase activity. Piper langum extract showed potent inhibition of antioxidant and scavenger of oxygen free radical activity (in vitro) and it induced oxidative stress.



Hypolipidemic, Triton WR-1339, Antioxidant, Lipid lowering activity.


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