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Research Journal of Pharmacy and Technology
Year : 2015, Volume : 8, Issue : 11
First page : ( 1526) Last page : ( 1528)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2015.00272.3

Clinical Comparison of the Efficacy and Safety of Intra-Articular Injections of Sodium Hyaluronate and Methyl Prednisolone in the Treatment of Osteoarthritis of Knee

Sarumathy S.*, Haripriya CH, Rao Muddala Vara Prasanna, Gayathri K., Sudhakar CH Bala, Divya M., Shanmugasundaram P.

Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels University (VISTAS), Pallavaram, Chennai-600117, India

*Corresponding Author E-mail: saruprabakar@gmail.com

Online published on 1 January, 2016.


The main objective of this study is to determine the safety and efficacy of the intra-articular injections (IA) of Sodium hyaluronate and methylprednisolone in the treatment of osteoarthritis (OA) of knee. The study was carried out in the orthopedic department of a multispeciality hospital for a period of 6 months from November 2013 to April 2014. Total number of 46 patients with OA of knee were categorized into two treatment groups, sodium hyaluronate (Group A, n= 26) and methylprednisolone (Group B, n= 20). Group A and B patients received sodium hyaluronate IA injection once a week for continuous 3 weeks and methylprednisolone IA injection once in 6 months. Pain score was assessed based on VAS (Visual Analogue Scale) and the recordings were done at baseline (1st visit), review 1 (2 weeks after IA injection), review 2 (4 weeks after IA injection) and review 3 (8 weeks after IA injection). ADRs for both the treatment groups were monitored and assessed. Sodium hyaluronate significantly reduced the VAS mean pain score with baseline-6.27, review 1–5.00, review 2–3.96 and review 3–3.15 for Group A patients and baseline-7.79, review 1–6.15, review 2–5.15 and review 3–5.68 for Group B patients. Edema and rashes were seen in Group A patients, similarly, edema and insomnia were seen in Group B patients which was mild to moderate. Sodium hyaluronate was safe and effective for OA of knee when compared with methylprednisolone.



Osteoarthritis, intra-articular injections (IA), Sodium hyaluronate, Methylprednisolone, Visual Analog Scale (VAS).


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