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Research Journal of Pharmacy and Technology
Year : 2012, Volume : 5, Issue : 8
First page : ( 1058) Last page : ( 1065)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.

Formulation development of antibacterial films containing mangosteen peel extract

Amnuaikit Thanaporn1, Phadungkarn Turawat1, Wattanapiromsakul Chatchai2, Boonme Prapaporn1,*

1Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla-90112, Thailand

2Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla-90112, Thailand

*Corresponding Author E-mail: prapaporn.b@psu.ac.th

Online published on 12 February, 2013.

Abstract

The aims of this study were to formulate films containing mangosteen peel extract (MPE) and to investigate their physicochemical characteristics, mechanical properties, as well as antibacterial activity. The film backbone composed of natural biodegradable polymers, i.e. agar, sodium alginate and pectin. Propylene glycol and glycerin were also used as plasticizers. All film components used have been in a GRAS status. The films were prepared by casting and drying method. The in-house prepared MPE by column chromatography technique possessed 77.86±1.13% α-mangostin, an antibacterial marker. The optimal film formulation with area of 25x30 cm2was composed of 1-g agar, 1-g sodium alginate, 1.5-g pectin, 20-ml propylene glycol and 0.9-ml glycerin. It was selected to incorporate with MPE to obtain 160 mg/film or 0.213 mg/cm2antibacterial films. The obtained films were clear with yellow color and had smooth surface. Their physicomechanical characteristics, i.e. appearance, thickness, moisture uptake, tensile strength and elongation break were acceptable for application on the skin. X-ray diffraction patterns exhibited that the form of αmangostin was not changed after film incorporation. The active entrapment, assayed by HPLC using standard αmangostin as a marker, was higher than 90%. The antibacterial films had satisfied stability, active release via dissolution of the polymers, and antibacterial activity against harmful skin-infectious bacteria, i.e. S. aureus, S. epidermidis and P. acnes. It was concluded that MPE could be incorporated in films for treatment of skin infection.

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Keywords

antibacterial, α-mangostin, films, mangosteen peel extract.

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