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Research Journal of Pharmacy and Technology
Year : 2012, Volume : 5, Issue : 11
First page : ( 1452) Last page : ( 1456)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.

Synthesis and antibacterial activity of some new (2E)-1-(8-hydroxyquinolin-7yl)-3-(Aryl) prop-2-en-1-one, Derivatives of Chalcone

Chabukswar Anuruddha R.1,*, Kuchekar Bhanudas S.1, Lokhande Pradeep D.2, More Archana S.3, Ojha Neha S.1, Londhe Ashwini M.1

1Maharashtra Academy of Engineering And Educational Research's, Maharashtra Institute of Pharmacy, S.No.124, MIT Campus, Paud Road, Pune-411038, Maharashtra, India.

2Department of Chemistry, University of Pune, Pune-411007, Maharashtra, India.

3J.S.P.M.’s Jayawantrao Sawant College of Pharmacy & Research Hadapsar, Pune-411028, Maharashtra, India.

*Corresponding Author E-mail: anichem18@gmail.com

Online published on 12 February, 2013.

Abstract

Present work describes the synthesis of (2E)-1-(8-hydroxyquinolin-7-yl)-3-(Aryl) prop-2-en-1-one, derivatives of Chalcones. Starting material 8-hydroxy quinoline was acetylated and subjected to fries rearrangement reaction to yield 7acetaldehyde-8-hydroxy quinoline which on aldol condensation with various derivatives of benzaldehyde yields 13 compounds. The compounds have been characterized and evaluated for anti-bacterial activity. MIC values of the compounds showing higher zone of inhibition was found to be 100 μg/ml. The activity of the compounds can be attributed to the substitution of electronegative groups in the synthesized compounds.

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Keywords

anti-bacterial activity, benzaldehyde, Chalcone, electronegative, 8-hydroxyquinoline.

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