Comparative Cardiotonic Activity of Sida cordifolia Linn with Digoxin on Perfused Frog Heart. Dama Ganesh Y.*, Jori Mayuri P., Joshi Prajakta P., Deore Sumit R., Bidkar Jayant S. Department of Pharmacognosy, Sharadchandra Pawar College of Pharmacy, Dumbarwadi, Otur, Pune, Maharashtra, India *Corresponding Author E-mail: gydama2008@rediffmail.com
Online published on 3 April, 2013. Abstract The present study was undertaken to evaluate the cardiotonic activity of the infusion of roots of Sida cordifolia Linn belonging to family Malvaceae which is common throughout the tropical and subtropical plains all over India and Ceylon growing wild along roadside. The cardiotonic effect of infusion of roots of Sida cordifolia Linn was studied by using perfused frog heart assembly. In the present work infusion, dilution 1:1 (Infusion: Distilled water), 1:2 (Infusion: Distilled water), 1:4 (Infusion: Distilled water), are used to evaluate cardiac activity on isolated frog heart and labeled as A1, A2, A3, A4, respectively and compared with Digoxin B1-25μg/ml, B2-50μg/ml as a standard. Present preliminary studies confirm better cardiotonic activity of Sida cordifolia Linn than digoxin. A significant increase in height of force of contraction (positive ionotropic effect) and decrease in heart rate (negative chronotropic effect) was observed. Top Keywords Sida cordifolia Linn, Digoxin, cardiotonic activity. Top |