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Preparation and Evaluation of Mucoadhesive Microspheres Containing Heparin for Antiulcer Therapy Venkateswaramurthy N.*, Sambathkumar R., Vijayabaskaran M., Perumal P. Department of Pharmaceutics, JKK Nataraja College of Pharmacy, Komarapalayam-638183, India *Corresponding Author E-mail: murthyvenki@rediffmail.com
Online published on 3 April, 2013. Abstract Oral administration of unfractionated heparin enhances gastric ulcer healing without affecting the coagulation function. In order to localize the heparin at site on the gastric epithelium for improving the efficacy of anti-ulcer activity a mucoadhesive microspheres composed of Carbopol 934P and Ethyl Cellulose have been developed. Heparin microspheres were prepared by using Eudragit RS100 as matrix and Carbopol 934P as mucoadhesive polymer. The microspheres were prepared by emulsion solvent evaporation technique. The prepared microspheres were evaluated with respect to the particle size, production yield, encapsulation efficiency, shape and surface properties, mucoadhesive property, in vitro drug release. The preliminary results show great promise for this delivery strategy in the treatment of ulcer. Top | |
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