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Research Journal of Pharmacy and Technology
Year : 2010, Volume : 3, Issue : 3
First page : ( 840) Last page : ( 842)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.

Hepatoprotective Activity of an Aqueous Extract of Stem and Leaves of Boerhaavia diffusa Against Carbon Tetra Chloride Induced Hepatotoxicity in Rats

P. Venkatesh1,*, D Hepcy Kalarani1, A. Dinakar2

1P. Rami Reddy Memorial College of Pharmacy-Kadapa-516 003, Andhra Pradesh, India

2Vagdevi College of Pharmacy and Research Centre, Nellore-524 004, Andhra Pradesh, India

*Corresponding Author E-mail: pharmacy_pv@yahoo.co.in

Online published on 3 April, 2013.

Abstract

An aqueous extract of stem and leaves of Boerhaavia Diffusa (AEBD) was studied for hepatoprotective activity against Swiss albino rats with liver damage induced by Carbon tetrachloride (CCl4) at two dose levels 150 and 300 mg kg−1. AEBD exhibited a significant protective action on the liver evident by a reduction in the elevated levels of serum lyosomal enzymes namely Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), Alkaline Phosphatase (ALP) in CCl4 induced hepatotoxicity. Thus AEBD showed a dose dependent hepatoprotective activity.

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Keywords

Hepatoprotective activity, AEBD, Carbon tetrachloride.

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