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Research Journal of Pharmacy and Technology
Year : 2010, Volume : 3, Issue : 2
First page : ( 619) Last page : ( 621)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.

Microwave Mediated Synthesis and Antifungal Activity of Some 5-Benzylidene-2, 4-thiazolidinediones

Srinivas M.1, Satyanarayana K.1,*, Kumar S. Kiran2, Kumar N. Sravan2, Ajay V.2, Kishore N.2

1Department of Medicinal Chemistry, Mother Teresa College of Pharmacy, Ghatkesar, R.R. Dist., A.P, India

2Department of Medicinal Chemistry, Nagarjuna University, Guntur, A.P, India

*Corresponding Author E-mail: rajshaz@gmail.com; srinu_629@yahoo.co.in

Online published on 3 April, 2013.


A series of 5-benzylidene-2,4-thiazolidinedione derivatives were synthesized by employing microwave irradiation. The synthesis involves microwave irradiation of an aromatic aldehyde with 2,4-thiazolidinedione in sodium acetate/acetic acid in ethanol. The reaction was completed in 15–30 min with 68–82% yields and was environmentally friendly with easy workup. The synthesized compounds were evaluated for antifungal activity.


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