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Research Journal of Pharmacy and Technology
Year : 2009, Volume : 2, Issue : 4
First page : ( 628) Last page : ( 633)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.

Oligomeric Proanthocyanidines: Grape Seed Extract

Mutahar RK Mohamed1,2,*, Dinesh BM3, Kumar Vinod4

1Dept of Pharmaceutics, Pharmacy., Karpagam University. Coimbatore. T.N., India

2P.G. Dept of Pharmaceutics., Dr. H.L.T.College of Pharmacy, Kengal, Channapatna, Bangalore (Rural)-571 502. Karnataka State. (India)

3P.G. Dept of Pharmaceutics., K.L.E.S. College of Pharmacy., II Block. Rajajinagar. Bangalore. 560 010. Karnataka State. (India)

4Vibes India., Bangalore. 560 010. Karnataka State. (India)

*Corresponding Author E-mail: profmutahar@gmail.com

Online published on 8 April, 2013.


Proanthocyanidins (PCs) are a class of phenolic compounds that take the form of oligomers or polymers of polyhydroxy flavan-3-ol units. The (PCs) are an integral part of the human diet, and are found in high concentrations in Grape seed extract (GSE). Oligomeric Proanthocyanidins (OPCs) are the most abundant polyphenolic substances found in GSE. From the point of view of OPCs potential protective action towards cardiovascular disease and the oxygen free radical scavenger capacity, it has attracted considerable attention of the international scientific community during the last thirty years. The purpose of this article is to give a lucid explanation of the Structure, Monograph and Biological properties, and also shed a light on both the laboratory and clinical research of the OPCs obtained from GSE, and making them a potentially valuable therapeutic tool for the treatment of a variety of ill health conditions.



Flavonoid, Grape seed extract, Oligomeric Proanthocyanidins, Polyphenols.


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