Efficacy of nanocurcumin with application of iontophoresis on inflammatory arthritis patients Nivetha B.1,*, Rahmathunisha A.1, Lokeshwari K.1, Kumaresan A.2, Nikkitha Sai K.V.1, Yeseshivi L.1, Janani R.1 1Department of Physiotherapy, Saveetha college of Physiotherapy, Chennai - 602105 2Professor, Department of Physiotherapy, Saveetha College of Physiotherapy, Chennai - 602105 *Corresponding Author E-mail: nivethabalamurugan5@gmail.com
Online published on 13 June, 2022. Abstract Background Rheumatoid arthritis (RA) is a chronic inflammatory systemic disorder that primarily affects smaller joints characterized by periods of severe pain, stiffness, and swelling and destruction of the bones and cartilage. As indicated by past investigations, oral organization of curcumin results in calming impact regardless of its low bioavailability in patients. Objective This study aims to measure the efficacy of nanocurcumin particles with iontophoresis in inflammatory arthritis patients. Methodology Nanocurcumin were prepared by a process based on a wet-milling technique. In vitro anti inflammatory assay of nanocurcumin was determined by Bradford assay using bovine serum albumin (BSA) as the standard. The prospective study was done among a 10 patients from the reports obtained from March 2020 to October 2020 in Physiotherapy clinic, Madurai. Results All the curcumin-treated groups showed significant alleviation of inflammatory arthritic condition (p<0.05) when compared with inflammatory arthritic controls. Conclusion: Iontophoretic administration of curcumin may ameliorate arthritic symptoms significantly, and the effect is assumed to be due to better penetration and enhanced bioavailability. Geriatrics patients are supposed to be benefited fairly by this technique. Top Keywords Iontophoresis, Curcumin, Nanosize, Inflammation, Arthritis. Top |