In vitro screening of Anti-diabetic activity and Anti-inflammatory activity of leaves extract of Barleria gibsoni Dalz Tamboli Firoj A.*, More Harinath N. Department of Pharmacognosy, Bharati Vidyapeeth College of Pharmacy, Near Chitranagari, Kolhapur-416013, Maharashtra, India. *Corresponding Author E-mail: firojtamboli143@gmail.com
Online published on 30 April, 2021. Abstract Present study was to investigate antidiabetic and anti-inflammatory activity ethanol extract of leaves of plant Barleria gibsoni Dalz. in-vitro. As per phytochemical investigation the extracts show presence of Flavanoids, tannins and saponins. The ethanolic leaves extract of Barleria gibsoni Dalz with a dose of 10, 20, 30, 40 and 50 μg/ml, was taken for the activity and compared with the standard drug. Egg albumin denaturation and bovine serum fraction model was taken for activity and compared with Aspirin 10–50μg/ml. The samples at concentration (20, 40, 60, 80, 100μg/ml) were studied for antidiabetic effect on glucose transport across yeast cells and α-Amylase inhibition. The ethanol extract of leaves showed that significant result in both anti-inflammatory as well as antidiabetic models. However, these effects need to be confirmed using in vivo models and clinical trials for its effective utilization as therapeutic agents. Top Keywords Barleria gibsoni, In-vitro Antidiabetic assay, Anti-inflammatory assay, Metformin, Aspirin. Top |