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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2021, Volume : 14, Issue : 3
First page : ( 1289) Last page : ( 1292)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00228.6

In vitro screening of Anti-diabetic activity and Anti-inflammatory activity of leaves extract of Barleria gibsoni Dalz

Tamboli Firoj A.*, More Harinath N.

Department of Pharmacognosy, Bharati Vidyapeeth College of Pharmacy, Near Chitranagari, Kolhapur-416013, Maharashtra, India.

*Corresponding Author E-mail: firojtamboli143@gmail.com

Online published on 30 April, 2021.

Abstract

Present study was to investigate antidiabetic and anti-inflammatory activity ethanol extract of leaves of plant Barleria gibsoni Dalz. in-vitro. As per phytochemical investigation the extracts show presence of Flavanoids, tannins and saponins. The ethanolic leaves extract of Barleria gibsoni Dalz with a dose of 10, 20, 30, 40 and 50 μg/ml, was taken for the activity and compared with the standard drug. Egg albumin denaturation and bovine serum fraction model was taken for activity and compared with Aspirin 10–50μg/ml. The samples at concentration (20, 40, 60, 80, 100μg/ml) were studied for antidiabetic effect on glucose transport across yeast cells and α-Amylase inhibition. The ethanol extract of leaves showed that significant result in both anti-inflammatory as well as antidiabetic models. However, these effects need to be confirmed using in vivo models and clinical trials for its effective utilization as therapeutic agents.

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Keywords

Barleria gibsoni, In-vitro Antidiabetic assay, Anti-inflammatory assay, Metformin, Aspirin.

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