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Novel pencil graphite electrode for the determination of montelukast sodium in its pure and pharmaceutical dosage forms Sakur Amir Alhaj*, Nashed Dania**, Noureldin Imad Analytical and Food Chemistry Dept., Faculty of Pharmacy, Aleppo University, Syria. *Corresponding Author E-mail: profsakur@gmail.com
**dania.nashed92@gmail.com
Online published on 30 April, 2021. Abstract A new pencil graphite coated electrode was constructed to a potentiometric determination of montelukast sodium (MON). The coating material was a polymeric film consists of polyvinyl chloride (PVC), di-butyl phthalate (DBP), ion pair of drug and strontium nitrate reagent (SR). The sensor exhibited a Nernstian response with a mean calibration graph slope of (28.65 ± 0.07) mV/decade. The linearity range was (10−2-10−5) M, with detection limit 0.19μM and quantification limit 0.57μM. The proposed electrode works effectively in pH range (5–9.5) and the influence of proposed interfering species was negligible. The effectiveness of the graphite sensor continued in a period of time about (35) days. The validation of the newly constructed technique was assumed according to ICH recommendations. The results were studied in comparison with a reference method and the statistical analysis demonstrated that there was no difference in the proposed and previous published methods. Top Keywords Montelukast sodium-graphite electrode-potentiometric-polymeric film-strontium nitrate. Top | | |
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