A review on applications of Hydroxy propyl methyl cellulose and natural polymers for the development of modified release drug delivery systems
Khiste Rahul1*, Bhapkar Nilkanth1, Kulkarni Nilesh2
1Department Department of Pharmaceutical Chemistry, Marathwada Mitra Mandal's College of Pharmacy, Thergaon, Pune-411033, Maharashtra, India.
2Department of Pharmaceutics, PES Modern College of Pharmacy (For Ladies), Moshi, Pune-421 105, Maharashtra, India.
*Corresponding Author E-mail: firstname.lastname@example.org
Online published on 30 April, 2021.
This review summarizes applications of Hydroxy Propyl Methyl Cellulose along with Natural polymers for the development of modified release drug delivery systems. The HPMC was available in variety of grades which show different applications in drug delivery. The various grades of HPMC utilized for the variety of action e.g. Coating agent, Adhesion promoter, Targeted release of drug etc. The modified release drug delivery system one of the highly researched field in pharmacy. Even though it is researched and various modified release formulations available in market. The developing more safer approach for drug release is still area of research, which contain easier routes, safer excipients, highly specific target selective materials. Natural polymer show very less side effects as well as it achieves the desired release of drug, so they are the choice of majority of formulations. e.g. Guar gum, Chitosan and Xanthan gum used in various drug delivery systems. Guar gum Cefapodoxime proxetil floating tablet prepared Guar gum, Xanthan gum ophthalmic preparation. Chitosan used in waste water treatment and various biomedical fields like tissue engineering, buccal drug delivery, anticancer treatment etc. Pollulan nanocrystals were studied for the anticancer drug delivery. The review solely based on HPMC-Natural polymer application in Modified release of drug. The various grades of HPMC utilized for the variety of action.
HPMC, Natural polymer, Chitosan, Guar gum, Xanthan gum etc.