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Year : 2021, Volume : 14, Issue : 2
First page : ( 1142) Last page : ( 1148)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00205.5

A review on game-changing approach for the oral administration of lipophilic drug: SEDDS

Jena Digvijay, Devi Akila D*, Babikir Mohamed Amanalla Omer

Dept of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institution of Science, Technology and Advanced Studies, Pallavaram, Chennai-600117, Tamilnadu, India.

*Corresponding Author E-mail: akilaajcp@gmail.com

Online published on 30 April, 2021.


Oral administration is the most preferable route for drug administration. Now a day's more chemical substance exhibit low aqueous solubility resulting in poor bioavailability so unsatisfactory through oral route. SEDDS plays a major role to overcome the problem of the delivery of lipid drugs through this route. oil, surfactant, co-surfactant (Smix) are the backbone of SEDDS formulation. It can be categorized into SNEDDS and SMEDDS. High energy emulsification and low energy emulsification are two methods for formulation. Evaluation of SEDDS done by droplet size, morphology, zeta potential, dissolution studies. SEDDS is and advanced successful approach for delivery of low aqueous soluble drugs of anti-cancer, anti-viral, anti-bacterial as well as natural products. We must work more on SEDDS more products should be marketed for the benefit of mankind.



Lipophilic drugs, Self-emulsifying, Lipid delivery, Surfactants.


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