A comprehensive review on application of microwave irradiation for preparation of inclusion complexes with cyclodextrins
Kulkarni Nilesh S.1*, Gite Pallavi D.1, Munde Manoj K.1, Dhole Shashikant N.1, Khiste Rahul H.2
1Department of Pharmaceutics, PES Modern College of Pharmacy (For Ladies), Moshi, Pune412105, Maharashtra, India.
2Department of Pharmaceutical Chemistry, Marathwada Mitra Mandal's, College of Pharmacy, Thergaon, Pune, 411033.
*Corresponding Author E-mail: email@example.com
Online published on 30 April, 2021.
Solubility of a drug is the rate limiting step for the absorption of drug. The drugs which shows poor solubility in gastrointestinal tract fails to show therapeutic response and results in poor bioavailability. To improve solubility of a drug various carriers are available amongst them cyclodextrin is most popular choice of excipient. Cyclodextrins are a family of cyclic oligomers containing α-(1–4) linked D-glucopyranose units in the chair conformation. The cyclodextrin features a cavity which is hydrophobic and hydrophilic exterior. The most common cyclodextrins have six, seven, and eight glucopyranose units known as α, β and γ-cyclodextrins respectively. The cavity is limited by hydroxyl groups of different chemical character. These dimensions allow the inclusion of several types of guest molecules/drugs to form inclusion complexes. Because of host guest interaction, there is change in some properties of guest molecule. Various techniques are reported till today for the preparation of inclusion complex of cyclodextrins with drug to improve solubility as kneading, co-precipitation, solvent evaporation, spray drying, freeze drying and microwave irradiation. Microwave irradiation is an electromagnetic irradiation in frequency range of 0.3 to 300 GHz. Microwave irradiation chemistry is based on heating of materials by microwave dielectric heating effects. This phenomenon is material specific. The microwave irradiations have capacity to induce drying, polymeric crosslinkages/drug-polymer interaction and modify the crystal habit without the need for excessive heat, lengthy process and toxic reactants. Extensive literature survey revealed that Microwave irradiation technique has the capacity to improve the solubility of poorly water soluble drugs.
Cyclodextrin, Microwave irradiation, Solubility, Spray drying, Lyophilization.