Recent advancement of Ionic polysaccharide-based nanoparticles for Cancer therapy
Mondal Ranadip, Dey Debraj, Maity Subhasis, Giri Tapan Kumar*
NSHM Knowledge Campus, Kolkata-Group of Institutions, 124 BL Saha Road, Kolkata-700053, West Bengal, India.
*Corresponding Author E-mail: email@example.com
Online published on 30 April, 2021.
Most of the anticancer agents have a poor aqueous solubility and narrow therapeutic index which leads to toxicity in human bodies. The novel nanocarrier based drug delivery systems can circumvent the drawback of generally used drugs in cancer treatment. Among various types of polymers, polysaccharides are used for the preparation of nanocarrier due to easy availability, low toxicity, biodegradability, and biocompatibility. Moreover, ionic (cationic or anionic) polysaccharides contain different hydrophilic groups such as amino, carboxyl, and hydroxyl groups that is soluble in water and forms non-covalent bonds with mucosal membranes and biological tissues to provide mucoadhesion and bioadhesion characteristics. In addition, ionic groups present in the polysaccharide backbone are responsible for modification. Recently, many researchers are giving attention to ionic polysaccharide-based nanoparticles for cancer therapy. However, the findings are not collected and represented in a comprehensive way. This article bridges that lacuna. This review portrays the chemistry of ionic polysaccharides and different approaches used to prepare ionic polysaccharide-based nanoparticles as the vehicle of antitumor agents. In addition, this article reviews the current advancements of ionic polysaccharide-based nanoparticles for the delivery of anticancer drug.
Polysaccharides, Nanocarrier, Cancer therapy, Targeted delivery, Ionic, PH sensitive.