Effect of benzydamine hydrochloride loaded Nanosponge formulations against mouth ulcers in Albino wistar rats Dr Mrs Shaji Jessy1*, Vaswani Twinkle Haresh2 1Professor, Department of Pharmaceutics, Principal. K.M. Kundnani College of Pharmacy, 23 Jote Joy Building, Ram Bhau Salgaonkar Road, Cuffe Parade, Mumbai, Maharashtra, India. 2Student in Master of Pharmacy, Research Scholar, Department of Pharmaceutics, Principal. K.M. Kundnani College of Pharmacy, Cuffe Parade, Mumbai, Maharashtra, India. *Corresponding Author E-mail: idjessy.shaji@gmail.com
Online published on 30 April, 2021. Abstract Study here observes comparative effect of nanosponge loaded hydrogel of Benzydamine hydrochloride against combined effect of oro-dispersible tablet consisting of vitamin B complex; B2, B6 and B12, and Benzydamine hydrochloride loaded nanogel that was evaluated against standard to show efficacy. For this study thirty Albino Wistar male rats were selected. They were observed for healing score of the ulcers, and were analysed histologically. Rats were sacrificed on three, six, twelfth day of analysis. The histological score and the clinical examination showed that the efficacy of nanosponge hydrogel of Benzydamine hydrochloride and or odispersible tablet was effective as against the standard gel of Benzydamine hydrochloride as they release the drug in a controlled manner (due to incorporation in nanosponges) as compared to standard Benzydamine hydrochloride group. The groups treated with standard formulation, nanogel and orodispersible tablet with nanogel resulted a decrease in ulcer area after the third day and there was almost a complete healing after the twelfth day. The healing score for Benzydamine hydrochloride nanogel in combination with orodispersible tablet showed a better average healing score than the nanogel and standard. As compared to the control and blank group, standard gel, nanogel and combinative treatment showed lesser healing score. Benzydamine hydrochloride nanogel and combination treatment showed an increased state of mucosal repair, thus they can be used for treating mucosal ulcers effectively. Top Keywords Nanosponge, Orodispersible Tablet, Nanogel, Albino Wistar Rats, Mucosal Healing. Top |