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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2021, Volume : 14, Issue : 2
First page : ( 981) Last page : ( 985)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00175.X

Analytical method development and validation of thiocolchicoside and ibuprofen in tablet dosage form by UV-Spectrophotometry method

Ankush Jadhav P.*, Datar P.A., Kedar T.R., Kardile D.P., Shete R.V.

Department of Pharmaceutical Quality Assurance, Rajgad Dnyanpeeth's College of Pharmacy, Bhor, Tal. Bhor, Dist. Pune-412 206, Maharashtra.

*Corresponding Author E-mail: jadhavbrand@gmail.com

Online published on 30 April, 2021.

Abstract

A new, simple, accurate, precise and reproducible UV-Spectrophotometric method is being developed for the simultaneous estimation of ibuprofen and thiocolchicoside in tablet dosage form for first time. The stock solutions were prepared in methanol. The λmax for Thiocolchicoside and Ibuprofen were 256nm and 228nm respectively. The Thiocolchicoside, Ibuprofen obeyed Beer's law in concentration range of 0.4–1.2μg/ml and 0.5–2.5μg/ml respectively. Results of analysis of absorbance ratio method were analysed and validated for various parameters according to ICH guidelines for accuracy, precision, linearity, robustness, LOD and LOQ. The proposed method is highly sensitive, precise and accurate, therefore can be used for intended purpose.

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Keywords

Thiocolchicoside, Ibuprofen, Absorbance Ratio Method, Validation, ICH.

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