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Year : 2021, Volume : 14, Issue : 2
First page : ( 966) Last page : ( 970)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00172.4

Development and characterization of corticosteroid loaded lipid carrier system for psoriasis

Yadav Krishna, Singh Deependra, Singh Manju Rawat*

University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, Chhattisgarh, 492010, India.

*Corresponding Author E-mail: manjursu@gmail.com

Online published on 30 April, 2021.


Psoriasis is a highly complex autoimmune disease of skin with keratinocytes that differentiate abnormally. Because of the inaccessibility of the adequate delivery system, a very favored treatment approaches contemplating topical treatment with current delivery approach are unreliable in targeting disease symptoms. The current work involved the development and characterization of Triamcinolone acetonide loaded solid lipid nanoparticles (TAC-SLNs) and their invitro characterization. The findings revealed that SLNs would substantially increase TA drug permeation across the skin, limiting them to dermis epidermis and helping to achieve the full clinical value of medications. It was also able to sustain the release of drug from lipid carrier. The outcomes of this research concluded that SLNs may efficiently deliver corticosteroids for the efficient treatment of psoriasis.



Psoriasis, Hyperproliferation, Keratinocytes, Triamcinolone acetonide, Solid lipid Nanoparticles.


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