Formulation and evaluation of lignocaine hydrochloride topical gel
Kumbhar Smita, Matole Vinod*, Dr. Thorat Yogesh, Madur Saili, Patil Smeeta, Shegaonkar Anita
D.S.T.S. Mandal's College of Pharmacy, Solapur-413004, Maharashtra, India.
*Corresponding Author E-mail: firstname.lastname@example.org
Online published on 30 April, 2021.
Objective: The present research has been undertaken for the formulation and evaluation of lignocaine hydrochloride gel. It is used for topical use for the local anaesthetic activity. Methods: Carbopol 934 was used as a polymer in various batches. The ratio of Carbopol 934 was changed for various batches. Developed Formulations of Physicochemical parameters such as percentage yield, drug content, pH, Viscosity, Spreadability, Extrudability and In-vitro Diffusion study were carried out for developed batches of Lignocaine Hydrochloride. Results: Viscosity studies of various formulations Exhibited that Formulation F2 was better than that of F1 and F3. From among all the developed formulation, F2 Shows better rheological properties and excellent Extrudability. pH of the F2 Batch is Sufficient to treat the pain. Percentage yield and drug content of F2 batch is good than other batches. Results shows that the concentration of Carbopol 934 gives the good rheological properties and drug contents. In-vitro Diffusion studies were carried out, F2 batch shows better results than that of the other two batches i.e. 96.06%. Conclusion: It was concluded that F2 batch is the good than the other batches. So F2 batch is good for the topical use.
Lignocaine Hydrochloride, Carbopol 934, Topical gel, Formulation and evaluation, Invitro Diffusion Study.