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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2021, Volume : 14, Issue : 2
First page : ( 883) Last page : ( 886)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00157.8

Immunobioinformatics of rabies virus in various countries of Asia: Glycoprotein gene

Fadholly Amaq1, Ansori Arif N. M.1, Kharisma Viol D.2, Rahmahani Jola3, Tacharina Martia R.3*

1Doctoral Program in Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia.

2Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Malang, Indonesia.

3Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia.

*Corresponding Author E-mail: martia.rt@fkh.unair.ac.id

Online published on 30 April, 2021.

Abstract

The purpose of this study was to analyze the genomic information of the glycoprotein gene of rabies virus (RABV) in several countries of Asia. The genomics information of vaccine virus strain and some local isolates were retrieved from GeneBank® (National Center for Biotechnology Information, USA). Ten genomics informations are consist of ERA vaccine virus, two viruses from Indonesia, a virus from Myanmar, India, Nepal, South Korea, Japan, Sri Lanka, and Iran. This bioinformatics process the ten genomics data in order to find pattern in 1, 575 bp of glycoprotein gene of RABV. In conclusion, this study have revealed the data of homology, B-cell epitope prediction, genetic distance, and molecular phylogenic analysis of RABV in various countries of Asia. We indicated that the glycoprotein, the immunogenic surface protein of RABV, has important part for vaccine design.

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Keywords

Bioinformatics, Lyssavirus, Glycoprotein, Rabies, Vaccine.

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