Formulation and development of lamotrigine fast dissolving tablet by enhancing its solubility through solid dispersion
Adil Vinal*, Rajput Dharmendra, Jain Shailesh, Kapoor Vishal, Gupta Naveen
Department of Pharmaceutics, Madhyanchal Professional University, Bhopal, Madhya Pradesh, India
*Corresponding Author E-mail: firstname.lastname@example.org
Online published on 30 April, 2021.
Lamotrigine is an anticonvulsant drug used to treat depression and bipolar disorders. It acts primarily by obstructing the sodium-dependent voltage channel, thus reducing the level of the excitatory neurotransmitter. Solid dispersion is a newer technique to improve the solubility of poorly soluble drugs using appropriate polymer. In addition, faster onset of action and protection during its administration of rapidly dissolving tablets are becoming requirements for achieving better drug absorption. These are dissolved rapidly due to the presence of saliva without any need for water upon administration into the mouth. Lamotrigine solid dispersion was prepared using PVP K30 as polymer in the ratio (1: 1). A fast dissolving lamotrigine tablet was formulated using three different superdisintegrants (crosscarmellose, crospovidone, sodium starch glycolate (SSG)) in different ratios. Afterwards the formulated tablets were tested for their different parameters. The result of the in vitro dissolution study showed that the F1 formulation was the most successful as it was dissolved in a very short time containing a combination of crospovidone and SSG in the ratio (1: 2). Increased disintegration time was observed with the combination of crosscarmellose and crospovidone (1: 2) ratio.
Solid Dispersion, PVP K30, Super disintegrants, Solubility Enhancement, Direct Compression.