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Year : 2021, Volume : 14, Issue : 2
First page : ( 833) Last page : ( 837)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00147.5

Inhibitory effect of mosinone-A on immunohistochemical expression of inflammatory and angiogenic markers in 7, 12-dimethylbenz (a) anthracene induced hamster buccal pouch carcinogenesis

Govindasamy Sugunadevi1*, Kathiresan Suresh2

1Assistant Professor and Head, Department of Biochemistry, Dhanalakshmi Srinivasan College of Arts and Science for Women (Autonomous), Perambalur-621212.

2Associate Professor, Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar.

*Corresponding Author E-mail: g.devisuguna@gmail.com

Online published on 30 April, 2021.


The present study was investigated to judge the immune histochemical expression of inflammatory and angiogenic markers in DMBA induced hamster buccal pouch carcinogenesis. a complete variety of 24 golden Syrian hamsters were randomized into randomised into four teams of six animals in each. Group I animals were served as untreated control. Groups II and III animals were painted with 0.5% DMBA in liquid paraffin three times per week for 14 weeks on the left buccal pouches. Group III animals were orally administered with Mosinone-A (2mg kg-1 b.wt) starting one week before the exposure to the carcinogen and continued on days alternate to DMBA painting, until the sacrification of the animals. Group IV animals were received Mosinone-A alone throughout the experimental period. Topical application of DMBA for 14 weeks induced buccal pouch carcinomas associated with increased expression of, cytokeratin-8 and iNos where as decreased expression of Cytokeratin. Oral administration of Mosinone-A significantly inhibited the development of HBP carcinomas as revealed by decreased expression of, Cytokeratin-8 and iNos increased expression Cytokeratin. The result of this present study indicates that Mosinone-A will exerts protective effects against DMBA induced buccal pouch carcinogenesis. These findings counsel that Mosinone-A exerts its malignant neoplasm properties by inhibiting cell proliferation and inducement differentiation and caspase mediated cell death.



Oral cancer, Mosinone-A, DMBA iNOS, Cytokeratin, Cytokeratin-8.


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