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Year : 2021, Volume : 14, Issue : 2
First page : ( 817) Last page : ( 822)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00144.X

Development and evaluation of ketoprofen sustained delivery system using Neem Gum

Harsha M Vijay, Baratam Srinivasa Rao*, Kishore A Krishna

St. Ann's College of Pharmacy, Department of Pharmaceutics, Andhra University Cantonment, Vizianagaram, Andhra Pradesh, India

*Corresponding Author E-mail: srinivas.baratam077@gmail.com

Online published on 30 April, 2021.


Background: The main objective of this work is to formulate a sustained release matrix tablets using neem gum. Ketoprofen was selected as a model drug due to the low biological half life, it requires frequent administration. Hence sustained dosage forms are formulated to reduce the dosage frequency. Methods: Ketoprofen matrix tablets were formulated by employing neem gum as a release rate retardant material and used in 10%, 20%, 30%, and 40% Concentration levels. Wet granulation method was used to develop sustained release tablets. Results: Tablet was evaluated in terms of flow properties of blended powders and the average weight, drug content hardness, in vitro dissolution studies and fourier transformation-infrared spectroscopy (FT-IR) were determined. Drug release was evaluated with zero and the first order for release kinetics, Higuchi, Korsmeyer peppas models for the release mechanism. The hardness of the tablets ranged from 5 to 7 Kg/cm2 and the friability values were less than 1% indicating that the matrix tablets were compact and hard. All the formulations satisfied the content of the drug as they contained 99.1 to 100.8% of Ketoprofen, KNS3 released 99.2 of drug in 12 hours and KNS4 released 90.13% of drug in 12 hours using neem gum and This data reveals that drug release follows fickian diffusion mechanism Peppas model. Conclusion: The present study could establish the suitability of neem gum as Controlled released (CR) polymer in the design of matrix tablets.



Ketoprofen, Neem Gum, Controlled Release and Wet Granulation Method.


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