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Year : 2021, Volume : 14, Issue : 2
First page : ( 813) Last page : ( 816)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00143.8

The protective effect of Capsaicin (Capsicum annum L) against the induction of Aflatoxin B1 in hepatocytes: A study of liver Histopathology in mice (Mus musculus)

Mohammad Sukmanadi1, Effendi Mustofa Helmi2*

1Department of Basic Veterinary Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, Indonesia.

2Department of Veterinary Public Health, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, Indonesia.

*Corresponding Author E-mail: mheffendi@yahoo.com

Online published on 30 April, 2021.


Background: Interaction bioinformatics analysis research and prediction of protein gene panel identification as a target of evaluating the effects of damage by AFB1 that induces hepatic injury1. Capsaicin compounds are active2: 1). Activating apoptosis, 2). Inducing the cell cycle, 3). cell-regulation viability of transcription expression factors. Objective: Proving that capsaicin inhibits the expression of AKT1 and MAPK1 target proteins in mice due to the induction of AFB1 in silico and in vivo. Methods: Molecular docking (In silico) bioinformatics and hepatic lesions pathogenicity; congestion, degeneration, and necrosis (In vivo). Results: Molecular docking of Gibbs free energy is negative. Scoring synergistically inhibits the viability of the signaling pathway and prevents the occurrence of hepatic lesions. Conclusion: Capsaicin has been shown to have a protective effect against AFB-1 induction; by preventing the occurrence of hepatic lesions so that they have potential herbal medicine candidates as hepatoprotection.



Capsaicin, Aflatoksin B1, AKT1, MAPK1.


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